Intracellular Recording using Transmembrane Conductive Nanoparticles

3 Intracellular recording

Intracellular recording is the measurement of voltage or current across the membrane of a cell. It typically involves an electrode inserted in the cell and a reference electrode outside the cell. The electrodes are connected to an amplifier to measure the membrane potential, possibly in response to a current injected through the intracellular electrode (current clamp), or the current flowing th...

Intracellular recording in behaving animals.

Electrophysiological recordings from behaving animals provide an unparalleled view into the functional role of individual neurons. Intracellular approaches can be especially revealing as they provide information about a neuron's inputs and intrinsic cellular properties, which together determine its spiking output. Recent technical developments have made intracellular recording possible during a...

Necturus macubsus. II. Intracellular Recording

Cooperative Transmembrane Penetration of Nanoparticles

Physical penetration of lipid bilayer membranes presents an alternative pathway for cellular delivery of nanoparticles (NPs) besides endocytosis. NPs delivered through this pathway could reach the cytoplasm, thereby opening the possibility of organelle-specific targeting. Herein we perform dissipative particle dynamics simulations to elucidate the transmembrane penetration mechanisms of multipl...

Conductive Polymer Combined Silk Fiber Bundle for Bioelectrical Signal Recording

Electrode materials for recording biomedical signals, such as electrocardiography (ECG), electroencephalography (EEG) and evoked potentials data, are expected to be soft, hydrophilic and electroconductive to minimize the stress imposed on living tissue, especially during long-term monitoring. We have developed and characterized string-shaped electrodes made from conductive polymer with silk fib...